Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers
نویسندگان
چکیده
منابع مشابه
Trapping Poly(ADP-Ribose) Polymerase.
Recent findings indicate that a major mechanism by which poly(ADP-ribose) polymerase (PARP) inhibitors kill cancer cells is by trapping PARP1 and PARP2 to the sites of DNA damage. The PARP enzyme-inhibitor complex "locks" onto damaged DNA and prevents DNA repair, replication, and transcription, leading to cell death. Several clinical-stage PARP inhibitors, including veliparib, rucaparib, olapar...
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Inhibition of the DNA repair enzyme PARP-1 has been extensively investigated in the pre-clinical setting as a strategy for chemoor radio-potentiation. Recent evidence has suggested that PARP inhibitors may be active as single agents in certain rare inherited cancers which carry DNA repair defects. Potent PARP-1 inhibitors have entered early clinical trials in cancer patients in the last 3 years...
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ancer Res ontrast to endocrine-sensitive and human epidermal growth factor receptor 2 (HER2)–positive breast , novel agents capable of treating advanced triple-negative breast cancer (TNBC) are lacking. Poly ribose) polymerase (PARP) inhibitors are emerging as one of the most promising “targeted” theras to treat TNBC, with the intended “target” being DNA repair. PARPs are a family of enzymes in...
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The poly(ADP-ribose)polymerases (PARPs) catalyse the transfer of ADP-ribose units from the substrate NAD(+) to acceptor proteins, biosynthesising polyanionic poly(ADP-ribose) polymers. A major isoform, PARP-1, has been the target for design of inhibitors for over twenty-five years. Inhibitors of the activity of PARP-1 have been claimed to have applications in the treatment of many disease state...
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Phosphorylation is a very common post-translational modification event known to modulate a wide range of biological responses. Beyond the regulation of protein activity, the interrelation of phosphorylation with other post-translational mechanisms is responsible for the control of diverse signaling pathways. Several observations suggest that phosphorylation of poly(ADP-ribose) polymerase-1 (PAR...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.46.30069